The micron scale resolution achieved allows to distinguish \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}βA plaques typical of the APP/PS1 AD mice, as well as to define sub-plaques details. This evidence concerns the gene PSEN1 and Alzheimer disease.