Hypoxia could obviously stimulate the CSC sphere formation of oxidized ATM lower tumor, but it only had mild induction effects on a high level of oxidized ATM-tumors (Fig. 2d, e), which are mainly due to hypoxia treatment efficiently stimulating the expression of oxidized ATM in oxidized ATM low group than that in oxidized ATM high group. The gene discussed is ATM; the disease is neoplasm.