PDHA1 and neoplasm: As shown in Fig. 6e, KU60019-mediated oxidized ATM inactivation correlated with the decreased GLUT1, PKM2 and PDHa, H4ac and SOX2 levels in xenograft tumors in comparison with the oxidized ATM-activated tumors, indicating that oxidized ATM facilitates tumorigenesis of TNBC-CSC and tumor growth via EMR-related acetyl-CoA accumulation.