For example, in the dorsolateral prefrontal cortex (DLPFC) and caudate, no differences were detected in HDAC1 or HDAC2 mRNA transcript levels between BD donor samples compared to controls14, while in the hippocampus SO-CA2/3 region, HDAC1 mRNA transcript levels were ~3-fold lower in BD donor samples compared to controls15. This evidence concerns the gene HDAC1 and Behcet disease.