CRB1 and retinal disorder: This work provides an overview of the mutational spectrum of IRD in Tunisian cohort (Fig. 5) which gives an the most frequent genes in our cohort of patients with retinal disorders were: 14% ABCA4 (p.E1087K, p.W782*, p.Y639C, p.P1380L, p.N380K and dup32-40; del45-47), 8% RPE65 (p.R91W, p.H182Y, p.R234* and c.1129-2A > G), 8% CRB1 (p.R764H, p.P836T, p.Y702C and c.3542 + 1G > A) with variable phenotypes of severe IRD, ranging from LCA to RP as previously reported17 and 8% CERKL (c.1133 + 3_1133 + 6delAAGT).