In previous studies, we also observed that miR-133a-3p, miR-5188, miR-3188, miR-374a, and miR-296-3p, respectively were modulated by VPS33B, HBx, FOXO1, PDCD4, and HDGF involving in the tumor pathogenesis induced by these genes5,6,12,13,20,24,25. This evidence concerns the gene HDGF and neoplasm.