ADAP2 and infection: While the expression of ADAP2 and GILT did not inhibit HCoV-OC43pp infection (Fig. 4B), expression of LY6E in Flp-In TREx 293 cells efficiently suppressed the infection of lentiviral particles pseudotyped with the envelope glycoproteins of all the human CoVs, except for SARSpp (Fig. 4C and D).