Preprocedural beta-blocker administration for patients undergoing TAVR was not associated with 2-year cardiovascular and non-cardiovascular mortality in overall, but was associated with a lower risk of 2-year cardiovascular mortality only in patients with a history of CABG, presence of PAD, BNP ≥400 pg/mL and post-LVEF <50%. Here, NPPB is linked to peripheral arterial disease.