TP53 and Cirrhosis: A study in Mexico found that persons with cirrhosis had high urinary levels of AFB1 adducts.21 In Brazil, an autopsy study found an association between AFB1 residues and chronic liver diseases, including cirrhosis.22 In contrast, a US study reported that the AFB1 signature mutation in TP53 was not evident in the tissue of individuals with cirrhosis.23