As it has been shown that IL-17A and IL-17C both require IL-17RA for the induction of inflammatory mediators in target cells and IL-17C promotes Th17 cell responses [11, 33, 34] we hypothesized that the specific IL-17C receptor IL-17RE has a function in OVA-induced experimental asthma. The gene discussed is IL17C; the disease is asthma.