MYCN and brain neoplasm: In the course of routine mutational profiling of 552 patients with CNS tumors reviewed in the Laboratory of Pathology, National Cancer Institute (USA) using a custom primary brain tumor specific next generation sequencing panel (PBTP) and/or the Oncomine Comprehensive Assay v3 (Thermo-Fisher Scientific), we identified 7 SP-EPN patients with high level MYCN amplification (Fig. 1a).