Therefore, we hypothesized that the rs12411216 mutation would lead to a decrease in glucocerebrosidase (GBA protein, GCase) and enzyme activity, after which abnormally expressed GBA would affect the transport and degradation of a-Syn, thereby accelerating the formation of Lewy bodies and promoting the pathogenesis of PD (Fig. 5). The gene discussed is GBA1; the disease is Parkinson disease.