IGF1 and neoplasm: As shown in Fig. 6b, it indicated that the COL1A1, IGF1, COL5A1, CXCL12, PTEN, and SPP1 were significantly differently expressed in EC tumor compared with those in normal samples (P = 4.93E−02, P = 5.24E−03, P = 2.83E−04, P = 1.58E−06, P = 2.11E−12, and P = 6.91E−13, respectively).