COL1A1 and COL5A1 all belong to the collagen family; this family is the major component of the tumor microenvironment, it interacts with substances in the ECM (such as matrix metalloproteinases), integrins, tyrosine kinase receptors, and some signaling pathways to influence tumor cell behavior and activity [11, 12]. The gene discussed is COL5A1; the disease is neoplasm.