TF and Tangier disease: Neghina and Anghel [27] conducted a meta-analysis examining the association between the various HFE genotypes and iron overload and found that in individuals with a clinical diagnosis of HH, the C282Y homozygous genotype had a 100 times greater association with an elevated transferrin saturation, serum iron, and serum ferritin when compared with H63D homozygotes.