This woman originating from Comoros islands experienced spleen infarct after a long-distance flight and showed the association of a HbS trait, SEA ovalocytosis (SLC4A1: p.Ala400_Ala408del), a G6PD MATERA A- p.V98M variant at heterozygous state [46], a homozygous SPTA1 variation (p.E2224D) and a PIEZO1 mutation (p.R457C) already involved in DHSt [16]. The gene discussed is PIEZO1; the disease is splenic infarction.