P34 had UH and iron overload, and variations in 3 genes: a homozygous p.H63D variation in HFE, which may contribute to iron overload even though its implication is not totally clear [55, 56], a heterozygous ABCG8 VUS and 2 heterozygous ADAMTS13 VUS. Here, ABCG8 is linked to Tangier disease.