It is hypothesized that GP-based follow-up care will not differ significantly with specialist-based follow-up care regarding the adherence to the prostate surveillance guideline regarding: the number of PSA measurements; the time from a BCR to prostate cancer retreatment decision-making; the management of treatment-related side effects as experienced by patients; health-related quality of life and prostate cancer-related anxiety; continuity of care and; and costs-effectiveness. The gene discussed is KLK3; the disease is prostate cancer.