BRD4 and cancer: In cancer development, BRD4 was a stimulator for the expression of cell proliferation related genes, such as c-Myc, CyclinD1 and CDK4 (Segura et al. 2013; Xiang et al. 2018), as well as cell migration related genes, such as MMP-2 and MMP-9 (Wang et al. 2015).