BBC3 and mucoepidermoid carcinoma: Another experiment carried out by Hyun-Ju Yu and co-authors showed that the extract of P. discolor caused a significant increase in the apoptosis of human mucoepidermoid carcinoma cells by increasing the expression of proapoptotic p53 upregulated modulator of apoptosis (PUMA) protein and reducing the phosphorylation signal transducers and activators of transcription [31].