Because the reduced activity of p70S6K may be associated with the decreased density of dendritic spines, and that NMDAR antagonists increase the density of dendritic spines in animal models of depression and naive rodents [49,50,51], we subsequently investigated the effects of ZnD and Ro on this parameter in the medial prefrontal cortex (mPFC). Here, RPS6KB1 is linked to major depressive disorder.