NLRP1 and corneal intraepithelial dyskeratosis-palmoplantar hyperkeratosis-laryngeal dyskeratosis syndrome: MSPC (multiple self-healing palmoplantar carcinoma) and FKLC (familial keratosis lichenoides chronica) are two rare monogenic inflammatory skin diseases, which are caused by gain-of-function (GoF) mutations of NLRP1 [43].