The finding that expression of the NLRP1 inflammasome, although GoF mutants of NLRP1 predispose for SCC development [43], is suppressed in SCC cell lines and existing SCC tumors [113] supports a dual, paradoxical and cell type, stage- and/or time-specific role of inflammasomes in (skin) cancer development. The gene discussed is NLRP1; the disease is skin cancer.