CCND2 amplification is not always correlated to increased transcripts or protein expression [117], and the mechanistic significance of the amplification is not currently understood, although the effect of CCND2 amplification may be mediated through pep5, a Cyclin D2-derived peptide, which has been shown in some cancers to inhibit cell growth or cause cell death [118,119]. Here, CCND2 is linked to cancer.