The association between full house immunostaining (staining for all immune reactants, IgG/IgA/IgM/C1q/C3) and membranoproliferative, mesangioproliferative or membranous pattern is highly suggestive for lupus nephritis, which explains why some authors consider HUVS as a SLE-related syndrome [13]. The gene discussed is C3; the disease is lupus nephritis.