Results showed that upregulation of RCC1 and PDCD5 and downregulation of ASPH, HSPB1, SQSTM1, ANXA2, GSN, PURA, and MX1, comparing PCa vs. normal prostate or normal adjacent to tumor tissue, correlated with a decrease in relapse-free survival of PCa patients, revealing the clinical importance of the HO-1 interactors classified into Groups A or B. This evidence concerns the gene PDCD5 and neoplasm.