IKBKB and rheumatoid arthritis: The IKK inhibitor sc-514 competes with ATP binding to IKK2 and represents a selective IKK2 inhibitor which reduced cytokine gene expression by inhibiting IkappaB-alpha phosphorylation/degradation, affecting NF-kappa B nuclear import/export as well as the phosphorylation and transactivation of p65 in cytokine-activated synovial fibroblasts derived from RA patients [156].