It is also not surprising that NRP1, NRP2, PLXNA1, PLXNA3, and PLXND1 were associated with poor prognosis, as their primary ligands SEMA3A, SEMA3C, SEMA3E, and SEMA3F were found to be predominantly functioning as tumor promoters based on previous published literatures and our previous pan-cancer analysis of SEMA3s [8,11,12,43]. This evidence concerns the gene SEMA3E and cancer.