NRP1, PLXNA2, PLXNA4, and SEMA3B-3E and SEMA3G showed a significant decrease (p < 0.0001), PLXNA1, PLXNA3, and PLXNB3 showed a significant increase (p < 0.0001), while NRP2, PLXNB1, PLXNB2, and PLXNC1, SEMA3A and SEMA3F showed no overall significant difference in tumors compared to that of normal samples averaged across all 33 cancer types (p > 0.05) (Figure 1A). The gene discussed is SEMA3F; the disease is cancer.