For example, PLXNA1 and PLXNA3, which were mainly upregulated in tumors, were mainly associated with poor prognosis, while NRPs, PLXNB3, PLXNC1 and PLXND1 had mixed association with survival (both advantage and disadvantage) that is cancer type specific, however, majority of the significant survival association were toward poor prognosis. The gene discussed is PLXNB3; the disease is cancer.