In summary, based on our systematic analyses of NRPs and PLXNs in terms of their expression, association with patient survival, immune subtype, and tumor infiltration, we found that NRP1, NRP2, PLXNA1, PLXNA3, PLXNB3, PLXNC1, PLXND1 were mainly associated with poor prognosis. Here, PLXNC1 is linked to neoplasm.