At the individual gene and cancer type level, PLXNA1 and PLXNA3 were found to be predominantly up-regulated, PLXNA4 was predominantly down-regulated, while NRPs and the rest of the PLXNs showed mixed up- and down-regulation in the 17 tested cancer types, although overall NRP1 expression was downregulated, and PLXNB3 was upregulated averaged across all the 33 cancer types. This evidence concerns the gene PLXNA4 and cancer.