Our analysis showed that PLXNA3, B2, and C1 were significantly upregulated, and NRP1, NRP2, PLXNA1, A2, A4 were significantly downregulated, while the rest of the members (PLXNB1, B3 and D1) were not differentially expressed in breast cancer tumors (Figure 6A). The gene discussed is NRP2; the disease is breast cancer.