NRP1, PLXNB2, and PLXND1 showed increased expression in C3 and C6, and decreased expression in C5, while PLXNB3 had increased expression in C4 and C5, indicating they may play both tumor promoter and tumor suppressor roles as C3 and C5 subtypes associated the most with better survival, but subtypes C4 and C6 associated with worse survival, respectively. The gene discussed is PLXNB2; the disease is neoplasm.