Regardless of the association of gene expression with tumor stemness scores, members of NRPs and PLXNS did show strong correlation with drug responses, with NRP1, NRP2, PLXNA1, PLXNA2, PLXNB1, PLXNB2, PLXNB3 and PLXNC1 showing the highest frequency of the correlation with cell sensitivity or resistance to a number of chemotherapeutic drugs. This evidence concerns the gene PLXNB3 and neoplasm.