Overall, our study demonstrated that NRP1, NRP2, PLXNA1, PLXNA3, PLXNB3, PLXNC1, and PLXND1 were mainly associated with more aggressive phenotype of cancers and may mainly play tumor promoter roles during cancer tumorigenesis and metastasis, while the rest of the PLXN members PLXNA2, PLXNA4, PLXNB1, and PLXNB2 were more associated with better prognosis and may primarily function as tumor suppressors. This evidence concerns the gene PLXNA2 and cancer.