At the individual gene and cancer type level, PLXNA1 and PLXNA3 were found to be predominantly up-regulated, PLXNA4 was predominantly down-regulated, while NRPs and the rest of the PLXNs showed mixed up- and down-regulation in the 17 tested cancer types, although overall NRP1 expression was downregulated, and PLXNB3 was upregulated averaged across all the 33 cancer types. The gene discussed is NRP1; the disease is cancer.