NRP1 and breast cancer: Interestingly, all the genes with decreased expression in breast cancer tumor, i.e., NRP1, NRP2, PLXNA1, A2, and A4, showed higher expression in normal-like tumors than in other more aggressive subtypes, although PLXNA1 and A2 also showed higher expression in basal type tumors, one of the most aggressive type of breast cancer subtypes (Figure 6B).