For instance, even though genes PLXNB1, PLXNB3, and PLXND1 showed no significant differential expression in breast cancer tumors compared to normal, their expression was associated either with less aggressive breast cancer subtypes (PLXNB1) or with more aggressive subtypes or had further deregulated expression in metastatic tumors (PLXNB3 and PLXND1). The gene discussed is PLXND1; the disease is breast cancer.