Our previous study on the comprehensive characterization of SEMA3s showed that SEMA3A, SEMA3C, SEMA3E, and SEMA3F are more likely to promote tumorigenesis and associate with poor prognosis, while the other SEMA3s are more likely to play a tumor suppressor role and generally associate with better prognosis [11]. The gene discussed is SEMA3E; the disease is neoplasm.