Notably, the majority of the genes that showed differential expression in tumors, except PLXNA3, SEMA3B and SEMA3D, were further dysregulated in the metastatic tumors, where PLXNA1 and PLXNB3 were further upregulated, whereas genes NRP1, PLXNA2, PLXNA4, SEMA3E, and SEMA3G were further downregulated in metastatic tumors (p < 0.0001). The gene discussed is PLXNA4; the disease is metastatic neoplasm.