VitD effects on RAAS could be explained in light of its downregulation on renin gene expression and its consequent up-regulative influence on the angiotensin converting enzyme-2 ACE2/Ang(1–7)/MasR pathway [12], which is known to have a protective role in the context of CAD and MI [12,45,46]. This evidence concerns the gene REN and myocardial infarction.