According to the Kaplan–Meier survival curves by different mRNA expression levels of hub genes of the bladder cancer with grade 3 carcinoma, GSN, PDLIM4, and HTRA1 were identified as prognostic genes (log-rank test: p = 5.796 × 10−5; log-rank test: p = 9.952 × 10−6; log-rank test: p = 0.009244). The gene discussed is HTRA1; the disease is urinary bladder carcinoma.