On the other hand, hub genes identified in the grade 3 carcinoma were also involved in the several molecular processes, which were associated with platelet-derived growth factor (PDGF), insulin-like growth factor 1 (IGF-1) pathways, and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) pathways (Figure S3). The gene discussed is TNF; the disease is carcinoma.