It was first described in 2015 by Wang et al. [67] who found that HIF2PUT positively correlates with HIF-2α expression levels in osteosarcoma tissue and cell lines (R = 0.589, p = 0.013), and that overexpression and knockout of HIF2PUT could enhance or suppress HIF-2α mRNA levels, respectively. This evidence concerns the gene EPAS1 and osteosarcoma.