A further study by Wang et al. [60] revealed that melatonin acts as upstream regulator of CPS1-IT1 through increased forkhead box A2 (FOXA2) expression in hepatocellular carcinoma cells, proposing a melatonin/FOXA2/CPS-IT1/HIF-1α pathway. This evidence concerns the gene HIF1A and hepatocellular carcinoma.