In summary, considering the proposed VHL-dependent SARCC/AR/HIF-2α/c-MYC axis, VHL-wildtype RCC may experience a proliferation reduction under hypoxic conditions because of SARCC upregulation, whereas SARCC downregulation under hypoxia in VHL mutant RCC could lead to enhanced tumor proliferation [68]. Here, EPAS1 is linked to renal cell carcinoma.