EDN1 and type 1 diabetes mellitus: Suuronen and colleagues later showed that transgenic mice overexpressing human Glo1 under regulation of the preproendothelin-1 promoter were protected against T1DM-induced impairments in fractional shortening and ejection fraction, and that these protections were due in part to improvements in coronary microvascular endothelial function and attenuation in carbonyl stress [15].