Second, using video edge and live-cell confocal imaging, we showed that administering AAV2/9-Endo-Glo1 to rats a week after the onset of T1DM, attenuated impairments in myocyte contraction/relaxation kinetics and evoke Ca2+ transients that developed after eight weeks of chronic T1DM. Here, GLO1 is linked to type 1 diabetes mellitus.