After eight weeks of T1DM, the MG-H1 adduct was elevated on several Ca2+ cycling proteins including the ryanodine receptor (RyR2, 2.8 fold); myosin heavy chain beta (MHC-α/β, 2.9 fold); Na+:K+-ATPase (2.1 fold; sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2) (2.0 fold); potassium channel, Kv 4.2/4.3 (3.2 fold), and on mitochondrial NADH dehydrogenases (3.4 fold on NDUFV3 and 3.3 fold on NDUFV10; Figure 7E). The gene discussed is RYR2; the disease is type 1 diabetes mellitus.