GLO1 and type 1 diabetes mellitus: When Glo1 protein is reduced as is the case in T1DM hearts, elevation in MG (either within the coronary circulation or diffusion from juxtaposed cells) can impair nitric oxide-mediated vasodilation of endothelial cells as well as reduce expression of the tight junction protein resulting in coronary microvascular leakage and microbleeds [24].