Using existing information from studies that investigated the impact of alleles on different HBV outcomes to validate our statistical associations [53,82,83,84,85], we observed that out of 9 alleles, HLA-DRB*1301/2 and *0401 alleles—which had most epi—have been associated with spontaneous clearance of HBV infection [18,24,33,68,78,82,85,86,87], and HLA DRB1*0301 that had the least epi in our study has been previously associated with susceptibility to HBV infection, autoimmune hepatitis, chronicity, and non-responsiveness to HBV vaccination across different ethnic groups [9,88,89]. The gene discussed is HLA-DRB1; the disease is autoimmune hepatitis.