Therefore, we analyzed the impact of a ketogenic diet on lipid controls and cardiovascular risk markers and found similar results to previous studies [46,56,57] that evaluated the effects of a low-carbohydrate diet; our analysis revealed that a ketogenic diet decreased triglycerides while increasing total cholesterol secondary to increased LDL and HDL levels in patients with overweight or obesity, but no significant changes in other cardiovascular risk markers including blood pressure, CRP, and SCr were detected. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.