In addition, MASTL has been shown to regulate destruction of Cyclin B, enabling successful anaphase in diploid-immortalized human retinal pigment epithelial cells and several cancer cells, including osteosarcoma (U2OS), colon (HCT116) and cervical cancer (HeLa) [45], while demonstrating a possible stabilizing effect on Aurora A levels in neuroblastoma patient samples [46]. The gene discussed is MASTL; the disease is cancer.