For example, a recent study of newly diagnosed MM patients elegantly showed the interplay of genetic risk factors with dysregulated immune surveillance: patients that had MDS-associated phenotypic aberrations (MDS-PA) also exhibited dysregulated immune surveillance in the form of reduced frequency of naive γδ T-cells and expansion of CCR7 negative regulatory T-cells [128]. This evidence concerns the gene CCR7 and myelodysplastic syndrome.