In a cohort of CKD patients undergoing HD, with a median age of 53 years, Pelletier et al. investigated the association between sclerostin and bone status evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT) at the tibial site, and AAC assessed according to the Kauppila method on lateral spine imaging using dual-energy x-ray absorptiometry (DXA). Here, SOST is linked to chronic kidney disease.