NFE2L2 and neoplasm: Autophagy cargo-adaptor p62/sequestosome 1 (SQSTM1) [9,10,11], dipeptidyl peptidase 3 (DPP3) [12], Wilms tumor gene on X chromosome (WTX) [13], and Partner and Localizer of BRCA2 (PALB2) [14] all contain KEAP1-interacting region (KIR)-like ETGE motifs and thus competes with NRF2 for KEAP1 binding, resulting in KEAP1 sequestration and NRF2 stabilization.