NFE2L2 and cancer: In addition, two key glutaminolysis enzymes glutaminase (GLS2) and glutamic pyruvate transaminase 2 (GPT2) are activated by NRF2 and they control the production of glutamate, aspartate, alanine, and α-ketoglutarate, which are needed for nucleotides and nonessential amino acids synthesis in cancer cells [77].