NFE2L2 and neoplasm: In human ovarian cancer, weak NRF2-associated antioxidant defense in Treg cells leads to apoptosis induced by high ROS in tumor microenvironment and the apoptotic Treg cells abolish spontaneous and PD-L1-blockade-mediated antitumor T cell immunity, but sustain and amplify antitumor immunity via the adenosine receptor pathway [149].