Diabetic db/db mice crossed with Keap1 gene hypomorphic knockdown (Keap1flox/−) mice has revealed that genetic activation of NRF2 inhibits gluconeogenesis by suppressing glucose-6-phosphatase (G6PC), fructose-1,6-bisphosphatase 1 (FBP1), phosphoenolpyruvate carboxykinase (PCK1), peroxisome proliferator-activated receptor g coactivator 1-a (PGC1a), and nuclear receptor subfamily 4, group A, member 2 (NR4A2) in the liver, thereby preventing onset of Diabetes Mellitus [83]. This evidence concerns the gene G6PC1 and diabetes mellitus.