Characterized by early diagnosis of asthma (65 ± 14 months or 5.4 ± 1.2 years), decreased pulmonary function (low FEV1—82.28 ± 5.84%pred) and significant bronchial hyperreactivity (highest BDR 26.46 ± 13.4), with the highest worse clinical control (highest ACQ score, 2.32 ± 0.64), the highest titer of total IgE among clusters (486.4 U/mL) and the second highest result from specific IgE (0.269 ± 0.12 IU/mL). The gene discussed is IGHE; the disease is asthma.