Children with severe asthma, according to GINA, account for the highest percentage of atopic Cluster 3 (65% of patients in this Cluster), characterized by early onset of asthma (65 ± 14 months), high bronchial reversibility (the highest BDR), with the worst control (highest ACQ score) and highest total IgE titer. The gene discussed is IGHE; the disease is asthma.