CD79A and Cowden disease: IgA- and IgG-derived antibodies from both HDs and CD patients showed the typical pattern of highly mutated intestinal antibodies in both heavy and light chain V gene sequences (Barone et al., 2011; Benckert et al., 2011; Berkowska et al., 2015; Lindner et al., 2015; Fig. 6 A and, Fig. S3 E).