PLAC8 and infection: First, we determined whether Plac8 contributed to viral clearance by assessing lung viral titers from WT or Plac8-/- mice infected with 104 pfu of X31 (Fig 4A); however, there were no differences in viral titers on 3, 5, or 7 days post infection (dpi) between WT and Plac8-/- mice (Fig 4B) indicating that Plac8 does not significantly impact early CD8 T cell viral control.