After adjustment using the propensity score, as well as additional adjustment for history of premature CAD in a first-degree relative, length of index hospital stay, diabetes, hypertension, peripheral vascular disease, estimated glomerular filtration rate, and P2Y12 inhibitor and β-blocker use at discharge, the HR of CV mortality was 0.19 (95% CI, 0.06-0.56; P = .003). The gene discussed is P2RY12; the disease is diabetes mellitus.