Altered expression of HLA-G and imbalance of its isoforms was observed inepidermal cells of PV patients, suggestiong that HLA-G may act todiminish the deleterious effects of disease-promoting T lymphocytes orcontribute to the homeostatic balance of the skin at the end ofinflammation (Yari etal., 2008). The gene discussed is HLA-G; the disease is acquired polycythemia vera.