Inherent to cardiac status(stage C showing HF), drugs such as ACE inhibitors or angiotensin receptor blockers,were prescribed for 85.9 % of patients in group C, 22.9 % in group B1 and 20 % ingroup A (p = 0.963, p < 0.001, andp < 0.001, respectively). The gene discussed is ACE; the disease is hydrops fetalis.