In stage C patients compared withthose in stage A, genotypes DI or DD of the ACE I/D polymorphismwas more prevalent in patients with heart failure; p = 0.02, DIgenotype: OR = 2.52 [CI = 1.13 - 5.59] and DD genotype: OR = 2.59 [CI = 1.12 -5.95]. The gene discussed is ACE; the disease is heart failure.