Seven key genes (CEBPA, FLT3, PAX5, PAX8, RUNX1, TP53, and WT1) were obtained from PPIs network, most of which were reported to play a critical role in carcinogenesis and tumor progression (Junk et al., 2019; Rhodes, Vallikkannu, & Jayalakshmi, 2017; Slattery, Herrick, & Mullany, 2017). This evidence concerns the gene PAX8 and neoplasm.