Mutations or INDELs in 50 genes (PDE4DIP, NOTCH2, FANCA, BCR, CLTCL1, MYH11, NOTCH1, COL1A1, CAMTA1, ALK, NIN, CIITA, CARD11, RECQL4, USP6, NF1, NUP214, KIAA1549, MYH9, FLT3, NSD1, PCSK7, XPC, PMS2, SETBP1, SRGAP3, ASXL1, PDGFRA, ATIC, RALGDS, PRDM16, TSHR, FGFR2, EGFR, CDH11, DNM2, SYK, MUTYH, BCOR, FNBP1, RAC1, IL7R, CNOT3, RNF43, TP53, KCNJ5, MEN1, SH2B3, SRSF2, CREB3L1) were shared across all patients with leukemia. The gene discussed is RAC1; the disease is leukemia.