Mutations or INDELs in 50 genes (PDE4DIP, NOTCH2, FANCA, BCR, CLTCL1, MYH11, NOTCH1, COL1A1, CAMTA1, ALK, NIN, CIITA, CARD11, RECQL4, USP6, NF1, NUP214, KIAA1549, MYH9, FLT3, NSD1, PCSK7, XPC, PMS2, SETBP1, SRGAP3, ASXL1, PDGFRA, ATIC, RALGDS, PRDM16, TSHR, FGFR2, EGFR, CDH11, DNM2, SYK, MUTYH, BCOR, FNBP1, RAC1, IL7R, CNOT3, RNF43, TP53, KCNJ5, MEN1, SH2B3, SRSF2, CREB3L1) were shared across all patients with leukemia. Here, NOTCH2 is linked to leukemia.