The high prevalence of GNAQ, ELF4, HOXD13, and COX6C mutations in patients with APL were noteworthy, SMARCE1 variant predominated in patients with CML, variant of PER1 and ETV6 had higher frequencies in patients with AML. The gene discussed is HOXD13; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.