In a rat liver fibrosis model, MeCP2 expression is predominately associated with myofibroblastic cells and was found to selectively expressed in fibrotic tissues 19; however, in non‐trans‐differentiated cells MeCP2 expression is low,19, 22 and furthermore, MeCP2 acts as powerful epigenetic regulator for the genes related to myofibroblast trans‐differentiation, knocking down MeCP2 by siRNA increases the expression of PPAR‐γ.19, 22. The gene discussed is MECP2; the disease is Hepatic fibrosis.