Oxidized LDL‐induced oxidative stress in these BRCA2 mutation–positive individuals would further downregulate the expression of BRCA2, causing a situation with an almost complete loss of endothelial BRCA2, which might further exacerbate endothelial dysfunction, apoptosis, and atherosclerosis, warranting further investigation in humans. This evidence concerns the gene BRCA2 and atherosclerosis.