To investigate the potential involvement of BRCA2 in the atherogenic process in an atherosclerosis animal model, we evaluated the expression level of BRCA2 in the aorta of the high‐fat diet fed ApoE‐/‐ (ApoEnull) mice and compared it with the expression of BRCA2 in normal diet fed ApoE‐/‐ mice. This evidence concerns the gene APOE and atherosclerosis.