Oxidized LDL‐induced oxidative stress in these BRCA2 mutation–positive individuals would further downregulate the expression of BRCA2, causing a situation with an almost complete loss of endothelial BRCA2, which might further exacerbate endothelial dysfunction, apoptosis, and atherosclerosis, warranting further investigation in humans. Here, BRCA2 is linked to endothelial dysfunction.