As shown in Fig 6B, we found that C5a production was increased in macrophages from ANGPTL4 WT mice with pancreatitis (AP and SAP), whereas the level of C5a was reduced in macrophages from ANGPTL4−/− mice, compared with that in macrophages from ANGPTL4 WT mice. Here, C5AR1 is linked to alkaline phosphatase measurement.