Additionally, the high levels of C5a and C5aR expression that were observed in AP and SAP models were markedly decreased in ANGPTL4−/− AP and SAP models, as well as macrophage depletion models (Appendix Fig S7B and C), suggesting that ANGPTL4 induces severe pancreatitis by regulating C5a through a cause‐and‐effect relationship between ANGPTL4 and C5a. This evidence concerns the gene ANGPTL4 and pancreatitis.