Although the final body weight of HFD‐fed 20m OPN‐KO mice was similar to their age‐matched HFD‐fed WT mice (Figure S1D), they developed a greater degree of insulin resistance as demonstrated by the insulin tolerance test (ITT) (Figure S1E), insulin levels, and HOMA‐IR (Figure S1F). The gene discussed is SPP1; the disease is Insulin resistance.