As depicted in GSE7670, GSE10072, GSE18842, GSE19188, GSE27262, GSE31908, GSE33532, GSE75324, and TCGA LUAD datasets, compared with the normal lung tissues, purinergic receptors P2RX1, P2RX7, P2RY12, P2RY13, and P2RY14 were relatively downregulated in lung cancer tissues (Fig. 3). The gene discussed is P2RY13; the disease is lung carcinoma.