The high expression levels of pyrimidine metabolic rate–limiting enzymes CAD, CTPS, CTPS2, DHODH, DTYMK, NT5C2, NT5C3, RRM1, RRM2, TK1, TK2, TYMS, UCK2, and UCKL1 are illustrated in poorly differentiated liver cancer patients and correlated poor clinical outcomes [24]. The gene discussed is CAD; the disease is liver cancer.