Other tauopathies such as progressive supranuclear palsy (4R tau), corticobasal degeneration (4R tau), frontotemporal dementia (3R tau) and chronic traumatic encephalopathy (3R/4R tau) are characterised by different and distinct types and conformations of abnormally folded tau [25, 26]. Here, MAPT is linked to Classical progressive supranuclear palsy.