For example, compared to healthy controls, HDAC6 was elevated in the temporal cortex of donor samples from patients with frontotemporal lobar degeneration with TDP-43 inclusions (FTD-TDP43) [40] and in the frontal cortex and hippocampus from patients with Alzheimer’s disease [41, 42], as well as in tumors from patients with glioblastoma [34, 35]. This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.