However, examining the lung tissue 3 days post infection of SARS-CoV-2 virus in ACE2 transgenic mice showed colocalization of SARS-Cov-2 spike protein and ACE2 receptor on the cell surface7, 18, further supporting SARS-CoV-2 spike formed a stable interaction with ACE2 for the cell entry. The gene discussed is PROS1; the disease is infection.