High level of TNF - α has been associated in several inflammatory conditions and diseases such as malaria, coronary heart diseases, diabetes etc. In this study, there was a non-significant (p > 0.05) up-regulation of liver TNF-α gene in the group of rats administered 100 and 300 mg/kg body doses of T. didymostemon leaves extract in comparison to the control rats. Here, TNF is linked to diabetes mellitus.